HYPERADRENOCORTICISM (Cushing's disease) is a syndrome associated with hypercortisolaemia. Spontaneous disease is the result of either increased production of adrenocorticotrophic hormone (ACTH) by the pituitary gland (pituitary-dependent hyperadrenocorticism, PDH) or autonomous cortisol production by an adrenal neoplasm (adrenal-dependent hyperadrenocorticism, ADH). latrogenic Cushing's disease may also be seen following prolonged glucocorticoid administration. This article reviews the diagnosis and management of hyperadrenocorticism in the dog, emphasising the problem areas which may complicate diagnosis and management
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