COPPER absorption and metabolism is very complex, being influenced by many factors including the presence of antagonists (eg, molybdenum and sulphate) and species and breed variations in susceptibility. Of the major farm animals, sheep are the most susceptible to copper toxicity, followed by cattle, pigs and poultry, with estimated maximum safe dietary copper levels of 15, 100, 150 to 400, and 250 to 500 ppm, respectively. There are significant differences in susceptibility between breeds of sheep - North Ronaldsays being most susceptible, and Texels more so than Scottish Blackfaces.
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