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Companion Animal Practice
Mechanisms of immune-mediated disease in small animals
  1. Michael Day

    Michael Day qualified from Murdoch University, Western Australia, in 1982. After a short period in small animal practice he returned to Murdoch to complete a residency in microbiology and immunology, and a PhD involving collaborative research with the Royal Perth Hospital. Following postdoctoral positions in experimental immunology at the Universities of Bristol and Oxford, he was appointed lecturer (1990) and then senior lecturer (1997) in veterinary pathology at the University of Bristol. He is a diagnostic histopathologist and runs a clinical immunology diagnostic service. His research interests cover experimental models of autoimmunity and a range of companion animal immunemediated diseases.


A DISEASE may be considered to be immune-mediated when the pathology and clinical signs that characterise it arise following primary dysfunction of the immune system and no underlying disease is diagnosed. This article reviews the current knowledge of the mechanisms which underlie primary immune-mediated disease in small animals. An understanding of these mechanisms is important in formulating a prognosis for such disorders and in selecting appropriate immunomodulatory drugs for their treatment. The therapy of immune-mediated disease will be discussed further in an article in the next issue.

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