A DISEASE may be considered to be immune-mediated when the pathology and clinical signs that characterise it arise following primary dysfunction of the immune system and no underlying disease is diagnosed. This article reviews the current knowledge of the mechanisms which underlie primary immune-mediated disease in small animals. An understanding of these mechanisms is important in formulating a prognosis for such disorders and in selecting appropriate immunomodulatory drugs for their treatment. The therapy of immune-mediated disease will be discussed further in an article in the next issue.
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