PLASMA protein abnormalities are a significant biochemical finding in both dogs and cats. Changes in serum protein concentrations result in a variety of clinical signs and systemic effects and are associated with a number of disease processes. Due to the wide range of potential differential diagnoses for protein abnormalities, it is important that a methodical and logical approach is implemented in order to identify the primary disease. This article discusses the significance of changes in albumin, globulin and fibrinogen fractions within plasma and describes the diagnostic work-up for animals with abnormal protein levels.
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