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Companion Animal Practice
Significance of plasma protein abnormalities in dogs and cats
  1. Yvonne McGrotty

    Yvonne McGrotty graduated from Glasgow in 1997 and spent two years in small animal practice in Glasgow. She returned to the veterinary school in 1999 as a resident in small animal medicine and was awarded the certificate in small animal medicine in 2000. She is currently working as a resident in emergency medicine and critical care at the Royal Veterinary College.

  2. Clare Knottenbelt

    Clare Knottenbelt graduated from Bristol in 1994. After spending a year in mixed practice, she took up a residency in small animal internal medicine at the Royal (Dick) School of Veterinary Studies. She holds an MSc for studies in feline transfusion medicine, and the RCVS diploma in small animal medicine. She is currently lecturer in small animal medicine at Glasgow veterinary school.


PLASMA protein abnormalities are a significant biochemical finding in both dogs and cats. Changes in serum protein concentrations result in a variety of clinical signs and systemic effects and are associated with a number of disease processes. Due to the wide range of potential differential diagnoses for protein abnormalities, it is important that a methodical and logical approach is implemented in order to identify the primary disease. This article discusses the significance of changes in albumin, globulin and fibrinogen fractions within plasma and describes the diagnostic work-up for animals with abnormal protein levels.

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