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Companion animal practice
Use of non-steroidal anti-inflammatory drugs for the treatment of canine osteoarthritis
  1. John Innes

    John Innes graduated from Liverpool in 1991. He is professor of small animal surgery at Liverpool. In 2009, he co-founded Veterinary Tissue Bank, a veterinary tissue transplant supplier. He is an RCVS specialist in small animal orthopaedics.

    ,
  2. Turlough O'Neill

    Turlough O'Neill graduated from Dublin in 1987. He works in referral practice in Brighouse, West Yorkshire. He is an RCVS specialist in small animal surgery (orthopaedics) and a diplomate of the European College of Veterinary Surgeons.

    and
  3. Duncan Lascelles

    Duncan Lascelles graduated from Bristol in 1991. He is associate professor in small animal surgery at North Carolina State University College of Veterinary Medicine, USA, where he is also director of both the Comparative Pain Research Laboratory and the Integrated Pain Management Service. He is a diplomate of the European and American Colleges of Veterinary Surgery.

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of pharmaceutical in canine practice. Globally, the current oral NSAID market for chronic pain in small animals is estimated to be US$330 million, with the UK market valued at around US$47 million. As NSAIDs have developed, pharmaceutical companies have strived to optimise efficacy and reduce the incidence of adverse events, particularly those associated with the gastrointestinal system, through a greater understanding of basic pharmacology. This article discusses the latest innovations, including those relating to drug delivery and pharmacokinetics, in the NSAIDs used in dogs with osteoarthritis, which often requires long-term treatment.

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