Table 5:

Laboratory monitoring: interpretation of canine serum biochemistry when receiving phenobarbital

Biochemical parameterChanges suggestive of hepatic enzyme induction by phenobarbitalChanges suggestive of hepatocellular injury
Alanine aminotransferase (ALT)Less than 2 x the upper limit of normalMore than 2 x the upper limit of normal
Alkaline phosphatase (ALP)Up to 5 x upper limit of normalMore than 5 x upper limit of normal
γ- glutamyltransferase (GGT)Normal/minimal changesIncreased
Aspartate aminotransferase (AST)Normal/minimal changesIncreased
Changes suggestive of reduced liver function
BilirubinNormalIncreased
Bile acidsNormalIncreased
AlbuminNormalDecreased
CholesterolNormalDecreased
  • Reproduced from Rusbridge (2013a), reference Webster and Cooper (2009)