TableĀ 2:

Diagnostic work up for idiopathic epilepsy

Essential In ideal circumstances If indicated by other test findings
Detailed history
Clinical examination
Neurological examination
Fasting serum biochemistry (including resting bile acids, triglycerides, electrolytes, glucose)
Advanced imaging (MRI or CT)
Thyroid function*
Dynamic bile acids
CSF analysis
Serum cobalamin, folate, trypsin-like immunoreactivity
Faecal analysis
DNA tests
Organic acid urinalysis
  • * A diagnosis of hypothyroidism should not be made on the basis of thyroid hormone concentrations alone as epilepsy and phenobarbital therapy can result in a euthyroid sick syndrome

  • CSF Cerebrospinal fluid