TableĀ 2:

Relative potency of topical glucocorticoids

PotencyGlucocorticoid
Very potent glucocorticoids (up to 100 x hydrocortisone)Fluocinolone
Potent glucocorticoids (25-100 x hydrocortisone)Betamethasone
Dexamethasone
Hydrocortisone aceponate
Mometasone furoate
Moderate glucocorticoids (2-25 x hydrocortisone)Prednisolone
Triamcinolone
Mild glucocorticoidsHydrocortisone
  • This table should be used for guidance only, as the relative potency of topical glucocorticoids also varies with the concentration, formulation and preparation. Topical therapy is safer than systemic therapy but adverse effects can be seen, for example, the hypothalamic-pituitary-adrenal (HPA) axis can be affected for up to two to four weeks after otic administration of dexamethasone. Hydrocortisone aceponate and mometasone furoate show less local atrophy and systemic absorption than other glucocorticoids. Atrophic effects can be useful in reversing fibrosis and stenosis early in treatment, but may later interfere with epidermal migration allowing debris and desquamated cells to accumulate in the ear canals