Table 1:

Antimicrobials that can be effective in Pseudomonas otitis

AntimicrobialDelivery
Ciprofloxacin*0.2% solution 0.15-0.3 ml/ear q24h
Enrofloxacin15-20 mg/kg orally q24h; 2.5% injectable solution diluted 1:4 with saline or Epiotic (Virbac) topically q24h; 22.7 mg/ml solution 1 ml/ear q24h
Marbofloxacin5-10 mg/kg orally q24h; Aurizon (Vetoquinol) and Marbodex (Norbrook); 1% injectable solution diluted 1:4 with saline topically q24h; 20 mg/ml solution 1 ml/ear q24h
Ofloxacin*Ofloxacin 0.3% 0.15-0.3 ml/ear q24h
Carbenicillin*10-20 mg/kg intravenously q8h
Ceftazidime*25-50 mg/kg intravenously q8h; 100 mg/ml 1 ml/ear q12-24h
Silver sulfadiazine*#Dilute 0.1-0.5% in saline or trizEDTA; apply 1 ml q24h
Polymixin BSurolan (Elanco)
Amikacin*10-15 mg/kg subcutaneously q24h; 50 mg/ml 1 ml/ear q24h
Gentamicin5-10 mg/kg subcutaneously q24h; Otomax (MSD Animal Health) or Easotic (Virbac)
Tobramycin*Use eye drops or 8 mg/ml injectable solution 0.15-0.3 ml/ear q24h
  • * Not licensed for animals - these drugs and preparations should only be used where clinically justified under the Cascade and with the informed consent of the owners

  • Topical use in ears is not stated on the product label

  • Reconstituted solution stable for up to seven days at 4°C or one month if frozen

  • # Silver sulfadiazine shows additive activity with gentamicin and fluoroquinolones (although synergy has not been proven)